The pair have been appointed as overall programme management consultant, including for buildings, by Hellinikon, a subsidiary of Lamda Development.
The Metropolitan Park element is billed as one of the largest coastal parks in the world. Overall, the project is expected to attract at least a million new tourists a year.
In a press release sent to GCR, Mace and Jacobs said the work would create 10,000 construction jobs.
Planned structures include Athens’ first high rise residential project and a landmark mall.
The two companies previously teamed up on the London 2012 Olympics and Paralympics and Expo 2020 Dubai.
Lamda chief executive Odisseas Athanasiou said the scheme would be “a green, sustainable and smart city with excellent quality of life”.
The project would transfer “knowledge, know-how and new construction techniques to the Greek market over the coming years”, he added.
Jacobs senior vice president Donald Morrison said: “Our people bring extensive integrated project management and delivery experience in global re-development programs to support this exceptional opportunity to build a new Greek city.”